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Interaction Of Drug And Alcohol
Alcohol consumption can alter significantly the effect of
drugs, like anti-inflammatory, pain relievers, tranquilizers,
anxiolytics, sleeping pills, antidepressants,
antihypertensives, antihistamines, antipsychotics, and
interaction with alcohol alters the functioning of the drugs
and worse when drinking alcohol is acute or chronic.
These drugs have a growing consumption among the population,
and the effects of some of them can last for hours. The
pills, tranquilizers, anxiolytics, although taken evening
bedtime, remain on the central nervous system depressant
effect until the next day, decrease State of wakefulness,
care and reflexes.
Induction of liver enzymes which gives rise to an increase
of metabolism and a decrease of some drugs like
phenobarbital, meprobamato, phenytoin, warfarin,
paracetamol, antidiabetic effect occurs in patients who
consume alcohol chronic oral and rifampicin.
That is why alcoholics have tolerance for these drugs and
need higher doses of these drugs to achieve therapeutic
effect desired, except if they reach a situation of liver
cirrhosis of liver function is compromised and metabolism.
However, acute alcohol consumption causes inhibition of
metabolic enzymes and has been an increase in concentrations
of benzodiazepines, phenobarbital, chlorpromazine,
clometiazol, meprobamato, phenytoin, warfarin, antidiabetic
oral and paracetamol.
Alcohol can also increase the risk of gastric and prolong
bleeding time when eaten together with anti-inflammatory
mucosal lesions not drugs (NSAIDs) .the alcohol nor is must
ingest with acetaminophen because it increases the potential
toxic liver this analgésico-antipirético so widely used both
in the pediatric population level as in the adult.
In other situations it has been observed that the metabolism
of alcohol is inhibited by managing is alcohol and certain
medications together, this increases the concentration of
ethyl alcohol in the blood, in a disproportionate manner
which causes a series of unpleasant clinical manifestations
such as nausea, vomiting, sweating and reddening of the face,
few minutes alcohol ingestion patient, this phenomenon is
known as the antabuse effect.
These medications include disulfiram some cephalosporins (cefamandol,
cefoperazona cefotetán), the chlorpropamide, ketoconazole,
There are multiple interactions between drugs and alcohol.
In some cases can be beneficial because they reduce adverse
effects or increase efficiency, but in other cases can be
undesirable and lead to the failure of treatment.
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