Interaction Of Drug And Alcohol

Alcohol consumption can alter significantly the effect of drugs, like anti-inflammatory, pain relievers, tranquilizers, anxiolytics, sleeping pills, antidepressants, antihypertensives, antihistamines, antipsychotics, and interaction with alcohol alters the functioning of the drugs and worse when drinking alcohol is acute or chronic.

These drugs have a growing consumption among the population, and the effects of some of them can last for hours. The pills, tranquilizers, anxiolytics, although taken evening bedtime, remain on the central nervous system depressant effect until the next day, decrease State of wakefulness, care and reflexes.

Induction of liver enzymes which gives rise to an increase of metabolism and a decrease of some drugs like phenobarbital, meprobamato, phenytoin, warfarin, paracetamol, antidiabetic effect occurs in patients who consume alcohol chronic oral and rifampicin.

That is why alcoholics have tolerance for these drugs and need higher doses of these drugs to achieve therapeutic effect desired, except if they reach a situation of liver cirrhosis of liver function is compromised and metabolism.

However, acute alcohol consumption causes inhibition of metabolic enzymes and has been an increase in concentrations of benzodiazepines, phenobarbital, chlorpromazine, clometiazol, meprobamato, phenytoin, warfarin, antidiabetic oral and paracetamol.

Alcohol can also increase the risk of gastric and prolong bleeding time when eaten together with anti-inflammatory mucosal lesions not drugs (NSAIDs) .the alcohol nor is must ingest with acetaminophen because it increases the potential toxic liver this analgésico-antipirético so widely used both in the pediatric population level as in the adult.

In other situations it has been observed that the metabolism of alcohol is inhibited by managing is alcohol and certain medications together, this increases the concentration of ethyl alcohol in the blood, in a disproportionate manner which causes a series of unpleasant clinical manifestations such as nausea, vomiting, sweating and reddening of the face, few minutes alcohol ingestion patient, this phenomenon is known as the antabuse effect.

These medications include disulfiram some cephalosporins (cefamandol, cefoperazona cefotetán), the chlorpropamide, ketoconazole, metronidazole.

There are multiple interactions between drugs and alcohol. In some cases can be beneficial because they reduce adverse effects or increase efficiency, but in other cases can be undesirable and lead to the failure of treatment.



 

   

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